论文部分内容阅读
目的探讨了创伤性骨折患者治疗前后血清IL-6、IL-18和TGF-β1水平检测的变化及临床意义。方法应用放射免疫分析法和酶联法对31例创伤性骨折患者进行了治疗前后血清IL-6、IL-18和TGF-β1水平检测，并与35名正常健康人作比较。结果创伤性骨折患者在治疗前血清IL-6、IL-18和TGF-β1水平均非常显著的高于正常人组（P0.05），血清IL-6、IL-18和TGF-β1水平呈显著正相关（r=0.47820.5134.，P<0.01）。结论血清IL-6、IL-18和TGF-β1水平的变化与骨折的愈合密切相关。“,”Objective : To explore the clinical significance of changes of serum IL-6、IL-18 and TGF-β1 levels both before and after treatment in patients with facture. Methods : serum IL-6 、TGF-β1(with RIA). Serum IL-18(with ELISA) levels where measured in 31 patients with facture and 35 controls. Result : Before treatment, serum IL-6、IL-18 and TGF-β1 levels in the patients were significantly higher than those in controls (p0.05). serum IL-6 levels where positive correlated with IL-18 and TGF-β1 levels(r=0.4782 0.5134 p<0.01). Conclusions: The levels of serum IL-6、IL-18 and TGF-β1 might be correlated to the potential capability of fracture healing.