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目的 评价术前经导管肠系膜上、下动脉灌注抗癌药物治疗大肠癌的临床价值。材料与方法 病理证实的 5 1例大肠癌术前选择性肠系膜上、下动脉插管灌注抗癌药物 1～ 2次 ,5～ 3 0天 (平均 12天 )后行手术切除 ,标本送病理切片行组织学疗效观察 ,病例术后随访。结果 肿瘤组织学疗效有效率 98.0 % ,临床症状明显改善率 90 .2 % ,手术根治性切除率 92 .1%。随访时间 3～ 75个月 ,其中随访 2 4个月以上 3 2例 ,随访 60个月以上 15例 ,1、3、5年生存率分别为 92 .9%、76.6%、72 .8% ;术后 2年内复发率为3 .1% ( 1/ 3 2 ) ;动脉灌注化疗后 3天发生急性肠梗阻 3例 ,发生率为 5 .9% ( 3 / 5 1)。结论 术前经导管动脉灌注抗癌药物治疗大肠癌组织学疗效显著 ,可减轻患者临床症状 ,提高手术根治率 ,降低术后转移率和复发率 ,可提高生存率。
Objective To evaluate the clinical value of preoperative transcatheter mesenteric and inferior arterial infusion of anticancer drugs in the treatment of colorectal cancer. Materials and Methods Pathology confirmed 5 1 cases of colorectal cancer preoperative selective superior mesenteric artery perfusion anticancer drugs 1 to 2 times, 5 to 30 days (average 12 days) after surgical resection, the specimens sent to the pathological section Line histological observation, case follow-up. Results The effective rate of tumor histology was 98.0%, the clinical symptom improvement rate was 90.2% and the radical resection rate was 92.1%. The follow-up time ranged from 3 to 75 months. Among them, 32 cases were followed up for more than 24 months, and 15 cases were followed up for more than 60 months. The 1-, 3-, and 5-year survival rates were 92.9%, 76.6% and 72.8%, respectively. The recurrence rate was 3.1% (1/32) within 2 years after operation. There were 3 cases of acute intestinal obstruction 3 days after arterial infusion chemotherapy, with a rate of 5.9% (3/5 1). Conclusion Preoperative transcatheter arterial infusion of anticancer drugs in the treatment of colorectal cancer histological significant effect, can reduce the clinical symptoms, improve the cure rate of surgery, reduce the postoperative metastasis rate and recurrence rate, can improve the survival rate.