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[目的]探讨血清血管内皮生长因子-C(vascular endothelial growth factor C,VEGF-C)与肺腺癌淋巴结转移的关系。[方法]采用酶联免疫吸附法(ELISA)检测160例淋巴结转移区域不同的肺腺癌患者和40例健康体检者血清VEGF-C水平。[结果]肺腺癌患者血清VEGF-C水平高于正常人(P﹤0.05);血清VEGF-C水平在患者性别、年龄方面差异无统计学意义(P﹥0.05),与患者淋巴结转移成正相关,区域淋巴结转移越晚者血清VEGF-C水平越高(P﹤0.05)。[结论]肺腺癌患者血清VEGF-C水平升高,可能与肺腺癌的淋巴结转移有关。血清VEGF-C水平可作为推断肺腺癌淋巴结转移的参考指标。
[Objective] To investigate the relationship between serum vascular endothelial growth factor C (VEGF-C) and lymph node metastasis in lung adenocarcinoma. [Methods] Serum levels of VEGF-C in 160 patients with lung adenocarcinoma with lymph node metastasis and 40 healthy subjects were detected by enzyme-linked immunosorbent assay (ELISA). [Results] The serum level of VEGF-C in patients with lung adenocarcinoma was significantly higher than that in normal people (P <0.05). The serum level of VEGF-C had no significant difference in sex and age (P> 0.05), which was positively correlated with lymph node metastasis , The later the regional lymph node metastasis serum VEGF-C level is higher (P <0.05). [Conclusion] The serum level of VEGF-C in patients with lung adenocarcinoma is elevated, which may be related to the lymph node metastasis of lung adenocarcinoma. Serum VEGF-C levels can be used as a reference to infer the lymph node metastasis of lung adenocarcinoma.