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Aims: The 6-min walk test(6-MWT) is used to estimate functional capacity. However, in elderly patients with chronic heart failure(CHF):(i) 1 year reproducibility of the 6-MWT;(ii) sensitivity of the 6-MWT to self-perceived changes in symptoms of heart failure; and(iii) implications for patient numbers required for studies using the 6-MWT as an endpoint have not been described. Methods and results: One thousand and seventy-seven patients with CHF, aged >60, with NYHA Class ≥II were recruited. Heart failure symptom assessment was determined using a questionnaire related to aspects of physical function, and patients performed a baseline 6-MWT, with follow-up 1 year later. Seventy-four patients with unchanged symptoms had an unchanged 6-MWT distance, with an overall intraclass correlation coefficient of 0.80(95%CI=0.69-0.87). Four hundred and twenty-three patients reported an improvement in symptoms during follow-up. There was a negative correlation(r=-0.55; P=0.0001) between Δsymptoms and Δ6-MWT(i.e. a reduced 6-MWT distance is associated with reduced symptom severity at follow-up). Five hundred and sixteen patients reported worsening symptoms of heart failure, a moderate inverse correlation(r=-0.53; P=0.0001) was displayed between Δsymptoms and Δ6-MWT. For all patients, irrespective of symptom status, a high inverse correlation(r=-0.75; P=0.0001) was evident. On the basis of the data for patients with unchanged symptoms, it is calculated that to detect an increase in 6-MWT of 50 m, with 90%power, a study size of approximately 120 is required. Conclusion: In elderly patients with CHF, the 6-MWT shows satisfactory agreement when repeated 1 year later. Change in 6-MWT distance is sensitive to change in self-perceived symptoms of heart failure.
However, in elderly patients with chronic heart failure (CHF) :( i) 1 year reproducibility of the 6-MWT; (ii) sensitivity of the 6-MWT to self-perceived changes in symptoms of heart failure; and (iii) implications for patient numbers required for studies using the 6-MWT as an endpoint have not been described. Methods and results: One thousand and seventy-seven patients with CHF, aged> 60, with NYHA Class ≥II were recruited. Heart failure symptom assessment was determined using a questionnaire related aspects of physical function, and patients performed a baseline 6-MWT with follow-up 1 year later. Seventy- Four patients with unchanged symptoms had an unchanged 6-MWT distance, with an overall intraclass correlation coefficient of 0.80 (95% CI = 0.69-0.87). Four hundred and twenty-three patients reported an improvement in symptoms during follow-up. There was a negative correlation (r = -0.55; P = 0.0001) between Δsymptoms Five hundred and sixteen patients reported worsening symptoms of heart failure, a moderate inverse correlation (r = -0.53; P = 0.0001) and Δ6-MWT (ie, reduced 6-MWT distance is associated with reduced symptom severity at follow- was all between Δsymptoms and Δ6-MWT. For all patients, irrespective of symptom status, a high inverse correlation (r = -0.75; P = 0.0001) was evident. On the basis of the data for patients with unchanged symptoms, it is calculated that to detect an increase in 6-MWT of 50 m, with 90% power, a study size of approximately 120 is required. Conclusion: In elderly patients with CHF, the 6-MWT shows satisfactory agreement when repeated 1 year later. Change in 6-MWT distance is sensitive to change in self-perceived symptoms of heart failure.