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成视网膜细胞瘤抑制蛋白(RB)在细胞增殖中具有关键性作用,肿瘤进展过程常发现通过RB传导的信号出现缺失。中央口袋结构和羧基端片段的相互作用对于细胞周期是重要的。尽管在家族性成视网膜细胞瘤中发现了RB氨基端(RBN)突变,但其作用机制并不明确。Hassler等最近得到了RBN的晶体
Retinoblastoma inhibitory protein (RB) plays a key role in cell proliferation. The process of tumor progression often reveals the absence of signal transduction through RB. The interaction between the central pocket structure and the carboxy-terminal fragment is important for the cell cycle. Although RB RB mutations are found in familial retinoblastoma, the mechanism of action is not clear. Hassler and others recently got crystals of RBN