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目的：了解庚型肝炎病毒（ＨＧＶ）合并／重叠其他肝炎病毒感染状况。方法：分别对４９７例不同病原的病毒性肝炎患者进行ＨＧＶＲＮＡ（ＲＴＰＣＲ）检测，对其中１８０例患者进行抗ＨＧＶ（ＥＬＩＳＡ）检测。结果：①ＨＧＶ在各型病毒性肝炎患者中总的合并／重叠感染率为７．８％（３９／４９７）。②ＨＧＶ合并／重叠感染丙型肝炎病毒感染率为１８．９％（１０／５３），高于其他肝炎病毒的合并／重叠感染率，Ｐ＜０．０１。③有输血史的病人ＨＧＶＲＮＡ阳性率（１６．０％，１２／７５）高于无输血史的患者（６．４％，２７／４２２），Ｐ＜０．０１。④合并／重叠ＨＧＶ感染组与非合并／重叠ＨＧＶ感染组比较，两组肝功能指标无统计学差异（Ｐ＞０．０５）。⑤抗ＨＧＶ的检出率为１２．８％（２３／１８０），但其中仅有２１．７％（５／２３）同时为ＨＧＶＲＮＡ阳性。结论：①输血是传播ＨＧＶ的主要途径之一，但ＨＧＶ也可经非输血途径传播。②ＨＧＶ致病性可能较弱。③抗ＨＧＶ阳性并不一定代表ＨＧＶ病毒复制。
Objectives: To understand the prevalence of hepatitis G virus (HGV) co-infection / overlap with other hepatitis viruses. Methods: HGV RNA (RTPCR) was detected in 497 viral hepatitis patients with different pathogenicity, and anti-HGV (ELISA) was detected in 180 of them. Results: ① The overall combined / overlapping infection rate of HGV in various types of viral hepatitis was 7.8% (39/497). (2) The infection rate of hepatitis C virus was 18.9% (10/53) in HPG combined / overlapping infection, which was higher than that of other hepatitis viruses (P <0.01). ③ The positive rate of HGVRNA in patients with blood transfusion (16.0%, 12/75) was higher than that in patients without blood transfusion (6.4%, 27/422), P <0.01. ④Compared with non-merged / overlapping HGV infection group, there was no significant difference in liver function between the two groups (P> 0.05). ⑤ The detection rate of anti-HGV was 12.8% (23/180), but only 21.7% (5/23) of them were HGVRNA positive at the same time. Conclusion: Blood transfusion is one of the main ways of transmitting HGV, but HGV can also be transmitted by non-transfusion route. ②HVV pathogenicity may be weak. ③ anti- HGV positive does not necessarily represent the replication of HGV virus.