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建立动物模型有助于阐明特应性皮炎 (ＡＤ)的发病机制和寻找有效的治疗途径。ＮＣ/ＮｇａＴｎｄ小鼠在一般实验室条件下发生自发性皮炎、血浆总ＩｇＥ升高与皮炎严重程度相一致 ,肥大细胞和分泌ＩＬ 4的ＣＤ4 +Ｔ细胞数目在皮损中升高。作者研究ＮＣ/ＮｇａＴｎｄ小鼠皮炎部位
Animal models help to elucidate the pathogenesis of atopic dermatitis (AD) and find effective ways to treat it. In NC / NgaTnd mice, spontaneous dermatitis occurs under normal laboratory conditions and the increase in total plasma IgE is consistent with the severity of dermatitis. The number of mast cells and CD4 + T cells secreting IL4 is elevated in the lesion. The authors studied the NC / NgaTnd mouse dermatitis site