论文部分内容阅读
[目的]探讨胃肠道癌术后种植转移的临床特征及预后。[方法]回顾性分析52例胃肠道癌并术后种植转移患者的临床资料和随访结果。[结果]在种植转移的原发胃肠道癌中,98.1%(51/52)病例为T4期,82.7%(43/52)为低分化腺癌,腹水量≥100ml占73.1%(38/52),术后常规化疗者占75%(39/52),术后常规化疗组与未化疗组的种植转移时间差异无统计学意义(P>0.05),胃肠道癌术后种植转移1、3、5年总生存率分别为84.0%、54.2%和15.8%;单因素生存分析显示,原发癌的TNM分期、腹水量、远处器官转移是影响患者预后生存的主要因素(P<0.05),而多因素分析显示远处器官转移是预后最为明显的危险因素(P<0.05)。[结论]种植转移的原发胃肠道癌的恶性程度高、分期晚、分化低,常规化疗不能有效预防种植转移癌,原发癌的TNM分期、术中腹水量、远处器官转移是种植转移主要的不良预后因素,其中远处器官转移是最为明显的危险因素。
[Objective] To investigate the clinical characteristics and prognosis of gastrointestinal cancer after transplantation. [Methods] The clinical data and follow-up results of 52 patients with gastrointestinal cancer who were implanted and transferred after operation were retrospectively analyzed. [Results] Among the patients with metastatic primary gastrointestinal cancer, 98.1% (51/52) cases were stage T4, 82.7% (43/52) were poorly differentiated adenocarcinoma, and the amount of ascites ≥100ml was 73.1% (38 / 52), postoperative routine chemotherapy accounted for 75% (39/52), postoperative conventional chemotherapy group and non-chemotherapy group, the difference was not statistically significant (P> 0.05), postoperative gastrointestinal cancer metastasis 1 , And the overall survival rates at 3 and 5 years were 84.0%, 54.2% and 15.8%, respectively. Univariate survival analysis showed that TNM stage, ascites volume and distant organ metastasis of primary cancer were the main factors influencing prognosis of patients (P < 0.05). However, multivariate analysis showed that remote organ metastasis was the most significant risk factor for prognosis (P <0.05). [Conclusion] The metastatic primary gastrointestinal cancer has high malignancy, late stage and low differentiation. Conventional chemotherapy can not effectively prevent the metastasis of cancer. The TNM staging of primary cancer, intraoperative ascites, distant organ metastasis The main adverse prognostic factors, distant organ metastasis is the most obvious risk factors.