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用羟氨苄青霉素,灭滴灵,胃必治、甲氰咪胍及安慰剂治疗106例幽门螺旋杆菌相关性胃炎(HPAG),疗程2周.上述药物的幽门螺旋杆菌(HP)清除率依次为60.9%、40.0%、23.8%、4.6%及0%.羟氨苄青霉素组和灭滴灵组的HP 清除率与安慰剂组比较有明显差异(P<0.05),而胃必治组和甲氰咪胍组与安慰剂组比较却无显著差异(P>0.05).胃炎好转率与HP 清除率完全一致,羟氨苄青霉素组最高(65.2%),灭滴灵组次之(40.0%),胃必治组(19.1%)及甲氰咪胍组(4.6%)无效.本文尚对胃必治疗效差的原因作了扼要讨论.
106 cases of H. pylori-associated gastritis (HPAG) were treated with amoxicillin, metronidazole, quetiapine, cimetidine and placebo for 2 weeks.The clearance rates of H. pylori in the above drugs were 60.9%, 40.0%, 23.8%, 4.6% and 0%, respectively.HP clearance rates in amoxicillin and metronidazole groups were significantly different from those in placebo group (P <0.05) There was no significant difference between the NP group and the placebo group (P> 0.05). The improvement rate of gastritis was completely consistent with the HP clearance rate, the highest in amoxicillin group (65.2%), the second in metyraprid group (40.0% Bixi group (19.1%) and cimetidine group (4.6%) is invalid.This article still on the stomach will be the cause of the treatment effect is briefly discussed.