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目的测定吸入支气管扩张剂后呼气流峰值 (PEF )增加的绝对值用于判定慢性阻塞性肺疾病 (COPD)患者气道阻塞及其可逆程度。方法 163例轻～中度患者在吸入喘乐宁 40 0μg后分别测定 FEV1 及 PEF增加的绝对值。结果 85例 (5 2 % )吸入支气管扩张剂后FEV1 改善率 14 .0 0 %± 1.0 1% ;FEV1 增加绝对值为 (2 .5 7± 0 .11) L ,PEF增加的绝对值为 (3 9.2± 8.7) L /min。吸药后 PEF增加的绝对值≥ 45 L/min的患者 ,与 FEV1 改善率相比较 ,有较高的特异性 (89.66%～ 91.43 % )。结论吸入支气管扩张剂后 PEF绝对值的变化可作为判断 COPD患者气道阻塞及其可逆程度的简便可行方法。
Objective To determine the absolute value of increase in expiratory flow (PEF) after bronchodilator inhalation to determine airway obstruction and its reversibility in patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and sixty-three patients with mild to moderate disease were enrolled in the study. The absolute values of FEV1 and PEF increase were measured after inhalation of salbutamol 40 μg. Results The improvement rate of FEV1 after bronchodilator inhalation in 85 patients (52%) was 14.0% ± 1.01%, the absolute value of FEV1 increase was (2.57 ± 0.11) L, the absolute value of PEF increase was ( 3 9.2 ± 8.7) L / min. Patients with an absolute PEF increase of ≥ 45 L / min after inhalation had a higher specificity (89.66% -91.43%) compared with FEV1 improvement. Conclusion The change of PEF absolute value after bronchodilator inhalation can be used as a simple and feasible method to judge the obstruction and reversibility of airway in patients with COPD.