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本文提出肿瘤中药物传输的三重介质模型·基于第(Ⅰ)部分流体动力学的计算结果,采用有限元方法,在不同初始和边界条件下求解了对流—扩散方程组·根据计算结果,详细分析了药物注射方式、分子量、淋巴、药物结合和坏死区等对抗体免疫球蛋白IgG及其片断Fab在肿瘤中浓度分布的影响·
This article proposes the triple media model for drug delivery in tumors. Based on the results of fluid dynamics calculations in part (I), the finite element method was used to solve the convection-diffusion equations under different initial and boundary conditions. Based on the calculation results, a detailed analysis was performed. The effects of drug injection, molecular weight, lymphatics, drug binding and necrosis area on the concentration distribution of antibody immunoglobulin IgG and its fragments Fab in tumors