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近年来,微流控器件在细胞分离和筛选中的应用发展迅速.一方面,微流控器件可以是研究血细胞运动、变形和黏附等行为的有力手段;另一方面,血细胞的这些流动行为也为微流控器件检测、筛选细胞提供了设计依据,二者密不可分.本文从血细胞,尤其是红细胞的流动行为出发,首先介绍产生变形、黏附等行为的基本机理,然后重点介绍和分析基于血细胞流动行为特点进行细胞筛选和分离的微流控器件及其功能特点.
In recent years, the application of microfluidic devices in cell separation and screening has developed rapidly.On the one hand, microfluidic devices can be a powerful tool to study the behavior of blood cell movement, deformation and adhesion; on the other hand, these flow behavior of blood cells Which provide the design basis for microfluidic devices to detect and screen the cells.This paper starts from the flow behavior of blood cells, especially erythrocytes, first introduces the basic mechanism of deformation, adhesion and other behaviors, and then focuses on the introduction and analysis based on blood cells Flow behavior characteristics of microfluidic devices for cell screening and separation and their functional characteristics.