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B族链球菌 ( GBS)是新生儿和幼儿侵袭性感染的主要病因。 a和 b型 GBS荚膜多糖 ( PS)是具有不同抗原性的结构异构体 ,本文旨在研究健康成人接种 a型 PS-破伤风类毒类 ( a- TT)或 b- TT结合疫苗能否诱导功能性交叉反应性抗体 ,并确定交叉反应表位。 试验将正常未孕女性
Group B Streptococcus (GBS) is the leading cause of aggressive infections in newborns and young children. GBS capsular polysaccharides (PSs) of type a and b are structural isoforms of different antigenicity and the purpose of this paper is to investigate the effects of vaccination of a-PS or tetanus toxoid (a-TT) or b-TT in healthy adults No induces functional cross-reactive antibodies, and identifies cross-reactive epitopes. The test will be normal non-pregnant women