Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian can

• 作 者: Yunlang Cai Xiaoqiang Tan Jun Liu Yang Shen Di Wu Mulan Ren Peilin Huang Dandan Yu
• 机 构: Department of Obstetrics & Gynecology,Zhongda Hospital,Southeast University,Medical College,Southeas
• 出 处: Chinese Journal of Cancer Research
• 发表日期: 2014年05期
• 关键词: cisplatin chemotherapy inhibiting progression inducing caspase purchased arrest

The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis.

The activation of the PI3K / AKT / m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3 / DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3 / DDP cells to cisplatin through inhibiting the activation of PI3K / Akt / m TOR signaling pathway and inducing cell cycle arrest and apoptosis.