论文部分内容阅读
目的探讨吸烟、饮酒、体重指数与食管鳞状细胞癌(esophageal squamous carcinoma,ESCC)发病风险的关系。方法采用流行病学调查的病例-对照研究方法,病例组4 229例均经组织病理学确诊,对照组4 133例均经内镜检查排除了早期ESCC和其他上消化道肿瘤,全部调查资料输入EXCEL表中,进行统计分析。结果吸烟、饮酒与ESCC发生无明显关联;经性别、诊断年龄、高低发区、家族史等因素调整后Logistic回归分析表明,低体重(I级BMI)人群ESCC发病风险高于正常体重者(II级BMI)(P<0.05,OR=4.87,95%CI=4.09～5.82);超重及肥胖(III+IV级BMI)人群ESCC的发病风险低于正常体重者(II级BMI)(P<0.05,OR=0.32,95%CI=0.28～0.37)。结论 ESCC的发生与吸烟、饮酒无关,与体重指数有关,低体重可能增加ESCC患病风险。
Objective To explore the relationship between smoking, alcohol consumption, body mass index and the risk of esophageal squamous carcinoma (ESCC). Methods According to the case-control study of epidemiological investigation, 4 229 cases were confirmed by histopathology, 4 133 cases in the control group were excluded from the early ESCC and other upper gastrointestinal tumors by endoscopy, all survey data input EXCEL table for statistical analysis. Results There was no significant correlation between smoking and alcohol consumption and ESCC. Logistic regression analysis showed that the incidence of ESCC in low-weight (grade I) people was higher than that of normal weight (II) by gender, age at diagnosis, incidence of hypertension, family history and other factors (P <0.05, OR = 4.87, 95% CI = 4.09-5.82). The risk of ESCC in overweight and obese (III + IV grade BMI) patients was lower than that in normal weight group (P <0.05) , OR = 0.32, 95% CI = 0.28-0.37). Conclusion The occurrence of ESCC has nothing to do with smoking and drinking, and is related to body mass index. Low body weight may increase the risk of ESCC.