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目的了解广西鼠疫病人、周围人群、宿主动物及指示动物血清F1抗体阳性率、抗体滴度水平及分布情况,为鼠疫防治工作提供科学依据。方法采用间接血凝试验(IHA)检测血清中的F1抗体。结果第1次(2000～2001年)检测56例鼠疫病人血清、108份正常人血清、144份鼠血清和109份指示动物血清,阳性血清数分别为56份、2份、1份和7份,阳性率分别为100%、1.85%、0.69%和6.42%;第2次(2006年)检测30份原鼠疫病人血清、126份正常人血清、235份鼠血清和278份指示动物血清,除了检出9份F1抗体阳性的鼠疫病人血清(阳性率为30%)以外,其它血清均为阴性结果。结论广西鼠疫病人经过5～6年的时间,70%左右的病人的F1抗体已经消失,30%左右的病人可检测到F1抗体,但其滴度明显下降,而周围人群、宿主动物及指示动物血清未检出阳性结果。
Objective To understand the positive rate of F1 antibody and the titer and distribution of F1 antibody in plague patients, peripheral populations, host animals and indicator animals in Guangxi and provide a scientific basis for the prevention and control of plague. Methods Indirect hemagglutination test (IHA) was used to detect F1 antibody in serum. Results The first (2000 ~ 2001) detection of 56 cases of plague patient serum, 108 normal serum, 144 serum and 109 indicators of animal serum, the positive serum were 56, 2, 1 and 7 , The positive rates were 100%, 1.85%, 0.69% and 6.42% respectively; the second (2006) tests were 30 serums of original plague patients, 126 normal serums, 235 serums and 278specific serums Nine serums of the F1 antibody-positive plague patients were detected (positive rate was 30%), and all other sera were negative. Conclusions The F1 antibody in 70% of the patients in Guangxi plague patients disappeared after 5-6 years. F1 antibody was detected in about 30% of patients in Guangxi plague patients, but its titer was obviously decreased. However, the surrounding population, host animals and indicator animals Serum did not detect positive results.