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哮喘不是单一的疾病。遗传学研究显示,哮喘是一种具有遗传模式的复杂性疾病。作者在美国图森西南沙漠地区发现链格孢子是引起生长在该地区儿童哮喘的唯一敏感的过敏原,然而该地区6岁的哮喘儿童仅有一半是由链格孢子过敏引起的,因此作者推测儿童哮喘可能存在有两种表现型,并在美国图森地区儿童呼吸疾病研究中心进行研究来证实。 对象与方法 对美国图森儿童呼吸疾病研究中心注册登记的1985年5月～1984年10月出生的1246例婴儿通过问卷调查,了解其父母的哮喘病史;随访3岁之前患下呼吸道疾病(LRIS)的发生和进展情况;了解喘息发作的年龄;喘息性LRIS就医情况,在儿童到6岁和11岁时再各进行问卷调查一次。这些儿童在年龄平均6岁时,对儿童和其父母进行皮肤划痕试验,采用屋尘螨,链格孢子,鸭茅草,轻率草,橄
Asthma is not a single disease. Genetic studies show that asthma is a complex disease with a genetic pattern. In the desert region of Southwest Tucson, the authors found that Alternaria is the only sensitive allergen that causes childhood asthma in the region, but only half of the 6-year-old asthmatic children in the region are caused by Alzheimer’s disease, so the authors speculate There may be two phenotypes for childhood asthma, as evidenced by studies conducted at the Children’s Respiratory Disease Research Center in Tucson, USA. Subjects and Methods A total of 1,246 infants born from May 1985 to October 1984 registered with the Tucson Center for Childhood Respiratory Diseases (USA) were surveyed by questionnaire to investigate their parents’ history of asthma. Patients with respiratory diseases (LRIS ); To understand the age of wheezing episodes; to see wheezing LRIS visits and to conduct further surveys of children aged 6 and 11 years. These children, when they were 6 years of age, had skin scratch tests on children and their parents using house dust mites, Alternaria, duck grass, ragweed, olive