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目的：探讨复方丹参与胞二磷胆碱（ＣＤＰＣ）联合应用治疗新生儿缺氧缺血性脑病（ＨＩＥ）的疗效。方法：随机分组对照：对照组、复方丹参治疗组、复方丹参加ＣＤＰＣ治疗组。观察临床神经症状恢复时间和２０项新生儿行为神经评分（ＮＢＮＡ），判定疗效。结果：复方丹参与ＣＤＰＣ治疗ＨＩＥ疗效相似，均能在７～９天使神经症状明显好转或消失，轻度为２天，中度为７天，重度在１２天左右。其中意识状态恢复最快，原始反射次之，肢体肌张力最慢。在ＮＢＮＡ评分方面Ａ组与Ｂ组间有显著性差异（ｔ＝２４２Ｐ＜００５），ＮＢＮＡ达满分时间Ａ与Ｂ有显著性差异（Ｐ＜００５）。Ｃ组与Ａ组间有显著性差异（ｔ＝２２４Ｐ＜００５）。结论：复方丹参治疗ＨＩＥ与ＣＤＰＣ疗效相似，联合应用复方丹参与ＣＤＰＣ比单用ＣＤＰＣ在ＮＢＮＡ评分恢复方面有明显优势。
Objective: To investigate the curative effect of compound salvia miltiorrhiza combined with citicoline (CDPC) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Randomized control group: control group, compound Danshen treatment group, compound Danshen plus CDPC treatment group. Observe the recovery time of clinical neurological symptoms and 20 newborn behavioral neurological score (NBNA), to determine the efficacy. Results: The efficacy of compound Salvia miltiorrhiza and CDPC in treating HIE was similar, both of which could significantly improve or disappear the neurological symptoms in 7-9 days. The mild symptoms were 2 days, moderate 7 days and severe 12 days. One of the fastest recovery of consciousness, the original reflection of the second, the slowest muscle tone. NBNA score in group A and group B were significantly different (t = 2 42P <0 05), NBNA reached the full sub-time A and B were significantly different (P <0 05). There was a significant difference between group C and group A (t = 224P <005). Conclusion: The efficacy of compound Salvia miltiorrhiza in the treatment of HIE is similar to that of CDPC. Combined use of compound Salvia miltiorrhiza and CDPC has obvious advantages in the recovery of NBNA score compared with single use of CDPC.