论文部分内容阅读
目的:研究绝经女性中冠脉钙化积分(CACS)与臂踝动脉脉搏波传导速度(ba PWV)之间的相关性。方法:从1918名社区人群筛选出546名无冠心病病史并可以进行CACS检查的绝经女性为样本,对其进行标准化问卷调查、实验室指标检测、ba PWV及CACS测量。根据CACS将研究对象分为CACS=0组和CACS>0组,并根据ba PWV四分位数进行分组,利用logistic回归分析冠脉钙化与ba PWV的相关性。结果:研究人群中CACS>0组87例(15.9%),CACS=0组459例(84.1%)。其中CACS>0组在年龄、BMI、高血压、收缩压、总胆固醇、低密度脂蛋白及糖尿病方面均高于CACS=0组。同时,CACS>0组ba PWV比CACS=0组高(27.6%vs.24.2%,35.6%vs.23.1%),两组间差异有统计学意义(P=0.011),并且Logistic回归发现,绝经女性年龄(OR=1.094,95%CI 1.039-1.152,P<0.001)、高血压(OR=1.933,95%CI 1.092-3.422,P=0.024)、ba PWV第三分位数(OR=2.435,95%CI1.141-5.196,P=0.021)、ba PWV第四分位数(OR=3.323,95%CI 1.594-6.930,P=0.001)是冠脉钙化的独立危险因素。结论:绝经女性ba PWV升高与CACS相关,ba PWV可以作为一种评估冠脉钙化程度和心血管风险的有效手段得以应用。
PURPOSE: To investigate the association between coronary calcium score (ACS) and brachial-ankle pulse wave velocity (ba PWV) in menopausal women. Methods: A total of 546 premenopausal women with no history of coronary heart disease and coronary heart disease were screened from 1918 community-based population and standardized questionnaires, laboratory tests, ba PWV and CACS were performed. The subjects were divided into CACS = 0 group and CACS> 0 group according to CACS, and grouped according to ba PWV quartiles. Logistic regression was used to analyze the correlation between coronary calcium and ba PWV. Results: Among the study population, 87 (15.9%) were in the CACS> 0 group and 459 (84.1%) in the CACS = 0 group. The CACS> 0 group was higher than CACS = 0 group in age, BMI, hypertension, systolic blood pressure, total cholesterol, low density lipoprotein and diabetes. At the same time, ba PWV in CACS> 0 group was significantly higher than that in CACS = 0 group (27.6% vs.24.2%, 35.6% vs.23.1%), with significant difference between the two groups (P = 0.011) (OR = 1.933, 95% CI 1.092-3.422, P = 0.024), ba PWV third quantile (OR = 2.435, P <0.001) 95% CI1.141-5.196, P = 0.021). The fourth quartile of ba PWV (OR = 3.323,95% CI 1.594-6.930, P = 0.001) was an independent risk factor for coronary artery calcification. CONCLUSIONS: The elevation of ba PWV in menopausal women is associated with CACS, and ba PWV can be used as an effective measure of coronary artery calcification and cardiovascular risk.