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多囊卵巢综合征(PCOS)是育龄妇女最常见的临床表现高度异质性的内分泌、代谢疾病,是无排卵性不孕的主要原因之一,发病率占育龄妇女的5%～10%。肥胖与PCOS存在紧密联系。PCOS患者中,约50%存在超重或肥胖,其中大部分表现为腹型肥胖。肥胖与一系列代谢紊乱有关,特别是伴胰岛素抵抗的高胰岛素血症和高雄激素血症,两者在PCOS的病理生理过程中发挥关键作用。肥胖易加重PCOS患者的胰岛素抵抗和高雄激素血症,导致肥胖型PCOS患者更易并发2型糖尿病、心血管疾病等远期并发症,同时因此而产生的多毛、痤疮及不孕等典型表现易导致PCOS患者焦虑、抑郁等心理疾病的发生率升高。
Polycystic ovary syndrome (PCOS) is the most common clinical manifestations of women of childbearing age highly heterogeneous endocrine and metabolic diseases, is one of the main causes of anovulatory infertility, the incidence of women of reproductive age, 5% to 10%. Obesity and PCOS are closely linked. About 50% of PCOS patients are overweight or obese, most of whom show abdominal obesity. Obesity is associated with a number of metabolic disorders, particularly hyperinsulinemia and hyperandrogenism with insulin resistance, both of which play a key role in the pathophysiology of PCOS. Obesity tends to exacerbate insulin resistance and hyperandrogenism in patients with PCOS, leading to obesity in patients with PCOS more complicated by type 2 diabetes, cardiovascular disease and other long-term complications, resulting in the typical manifestations of hirsutism, acne and infertility easily lead to PCOS patients with anxiety, depression and other psychological diseases increased the incidence.