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用双盲给药法观察双歧杆菌活菌制剂口服治疗20例肝硬化内毒素血症的效果.结果显示该制剂有明显降低内毒素血症的作用.有效率在治疗组和对照组分别为73.33%和15.38%,P<0.005.两种不同机制产生的内毒素血症动物模型在该制剂灌胃后鲎试验阴转数为3/5只.粪便菌群计数肠杆菌数量较治疗前减少,双歧杆菌数增加,提示双歧杆菌活菌制剂治疗机制可能通过抑制肠道革兰氏阴性杆菌生长,减少了内毒素的产生.
Double-blind method was used to observe the efficacy of oral treatment of viable Bifidobacterium oral preparations of 20 cases of liver cirrhosis endotoxemia results show that the preparation significantly reduce the role of endotoxemia effective rate in the treatment group and the control group were 73.33% and 15.38% respectively, P <0.005. The animal model of endotoxemia produced by two different mechanisms showed that the number of negative rotations was 3/5 after gavage, , Bifidobacteria increased, suggesting that the treatment of viable Bifidobacterium agents may inhibit the growth of intestinal Gram-negative bacilli and reduce the production of endotoxin.