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过敏性紫癜(HSP)是临床常见的血管变态反应性疾病,主要的诊断标准是有明显的紫癜疹,可伴以下1个或多个次要指征:弥漫性腹痛,皮肤等组织活检显示以IgA为主的沉积物,任何关节出现急性关节炎或关节痛症状,肾脏受损(血尿或蛋白尿)。根据临床症状的特点分为5型:皮肤型、关节型、腹型、肾型及混合型。治疗上尚无统一方案,主要是对症治疗,糖皮质激素可明显缩短病程,改善症状,并减少严重肾脏病变的发生。难治型HSP的治疗可选用免疫抑制剂、IVIG及血浆置换等。
Henoch-Schonlein Purpura (HSP) is a clinically common vascular allergic disease. The main diagnostic criteria are clear purpura, which may be accompanied by one or more of the following secondary indications: diffuse abdominal pain, skin biopsies, etc. IgA-dominated deposits, any joint showing signs of acute arthritis or joint pain, and kidney damage (hematuria or proteinuria). According to the characteristics of clinical symptoms are divided into 5 types: skin type, joint type, abdominal type, kidney type and mixed type. There is no uniform treatment program, mainly symptomatic treatment, glucocorticoid can significantly shorten the course of disease, improve symptoms and reduce the incidence of severe kidney disease. Treatment of intractable HSP may use immunosuppressive agents, IVIG and plasma exchange.