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用家兔四血管夹闭模型观察益气活血方对脑缺血再灌注损伤ＴＸＡ２、ＰＧＩ２及ｃＡＭＰ、ｃＧＭＰ的影响。在缺血３０分钟和再灌注４５分钟后，脑组织ＴＸＢ２含量明显升高（Ｐ＜０．０５），６—ｋｅ－ｔｏ—ＰＧＦ１α含量降低（Ｐ＜０．０５），血浆及脑组织ｃＡＭＰ含量升高（Ｐ＜０．０５），而血浆及脑组织ｃＧＭＰ含量无明显变化（Ｐ＞０．０５）。在缺血前静注益气活血方（４．４ｇ生药／ｋｇ），可明显抑制再灌注后脑组织ＴＸＢ２含量的增加（Ｐ＜０．０５），提高脑组织６—ｋｅｔｏ—ＰＧＦ１α含量（Ｐ＜０．０５），但对缺血及再灌注时血浆及脑组织ｃＡＭＰ含量的增加并无明显影响（Ｐ＞０．０５）。提示脑组织局部的ＴＸＡ２／ＰＧＩ２平衡失调与脑缺血再灌注损伤的发生发展密切相关。益气活血方通过改善脑组织局部ＴＸＡ２／ＰＧＩ２平衡而起到抗脑灌注损伤的作用
The effects of Yiqi Huoxue Recipe on TXA2, PGI2, cAMP and cGMP in cerebral ischemia-reperfusion injury were observed by rabbit four-vessel occlusion model. The content of TXB2 in brain tissue and the content of 6-ke-to-PGF1α in brain tissue were significantly increased at 30 minutes and 45 minutes after reperfusion (P <0.05) (P <0.05), while the content of cGMP in plasma and brain tissue showed no significant change (P> 0.05). Pretreatment with Yiqi Huoxue prescription (4.4g crude drug / kg) before ischemia could obviously inhibit the increase of TXB2 content (P <0.05) and the content of 6-keto-PGF1α in brain tissue after reperfusion (P < 0.05), but had no significant effect on the increase of cAMP content in plasma and brain tissue during ischemia and reperfusion (P> 0.05). Tip brain tissue local TXA2 / PGI2 imbalance and cerebral ischemia-reperfusion injury are closely related to the occurrence and development. Yiqi Huoxue Fang acts as an anti-brain perfusion injury by improving the local TXA2 / PGI2 balance in brain tissue