【摘 要】
：
The thalamostriatal pathway is implicated in Parkinson\'s disease (PD);however,PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex (CM/Pf,or the Pf in rodents) and the dorsal striatum (DS) remai
【机 构】
：
Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong
论文部分内容阅读
The thalamostriatal pathway is implicated in Parkinson\'s disease (PD);however,PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex (CM/Pf,or the Pf in rodents) and the dorsal striatum (DS) remain unclear.Therefore,we simultaneously recorded local field potentials (LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking.The dopamine-lesioned rats showed increased LFP power in the beta band (12 Hz-35 Hz) in the Pf and DS during both epochs,but decreased LFP power in the delta (0.5 Hz-3 Hz) band in the Pf during rest epochs and in the DS during both epochs,compared to control rats.In addition,exaggerated low gamma (35 Hz-70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state.Furthermore,enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion.Significant increases occurred in the mean coherence in both theta (3 Hz-7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs.During the treadmill walking epochs,significant increases were found in both the alpha (7 Hz-12 Hz)and beta bands for two coherence measures.Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD,contributing to some of the motor and non-motor symptoms of the disease.
其他文献
Background:The Historical Importance of Studies of Human Brain in Dementia Research rnThe collection of brain and related tissue has a long history [1].In terms of dementia,a more systematic examination of the relationship between brain pathology and clin
Recently,Khayachi et al.[1] showed that fragile X mental retardation protein (FMRP) is an active substrate of the small ubiquitin-like modifier (SUMO) pathway in neurons.FMRP SUMOylation is induced by the activation of metabotropic glutamate receptors (mG
Introduction rnRecurrent complex visual hallucinations are a core clinical feature of dementia with Lewy bodies (DLB) and are typically well-formed,often consisting of figures,such as people or animals [1].Despite the profound impact upon patients and car
A previous functional magnetic resonance imaging study reported evidence for parallel memory traces in the hippocampus:a controlled match signal detecting matches to internally-generated goal states and an automatic mismatch signal identifying unpredicted
Neuropathic pain is a chronic debilitating symptom characterized by spontaneous pain and mechanical allodynia.It occurs in distinct forms,including brushevoked dynamic and filament-evoked punctate mechanical allodynia.Potassium channel 2.1 (Kir2.1),which
Dear Editor,rnSleep is essential for survival in mammals, and there are many examples of how the brain fails to function properly without sleep.These include the importance of sleep for plasticity during development [1], memory formation and consolidation