Association of primary biliary cirrhosis with idiopathic thrombocytopenic purpura

• 作 者: Nobuyuld Toshikuni Ryumei Yama
• 机 构: Department of Internal Medicine,Department of Gastroenterology and Hepatology
• 出 处: 世界胃肠病学杂志（英文版）
• 发表日期: 2004年期
• 关键词: Primary biliary cirrhosis Idiopathic thrombocytopenic purpura Anti-platelet auto

Although both primary biliary cirrhosis (PBC) and idiopathic thrombocytopenic purpura (ITP) are autoimmune diseases, the association of the 2 diseases is rare. Here, we report a case of ITP that developed during the follow-up of PBC in a 74-yearold man. The patient had been diagnosed with PBC 12 years previously, and had received treatment with ursodeoxycholic acid. The platelet count decreased from approximately 60 × 109/L to 8 × 109/L, and the association of decompensated liver cirrhosis (PBC) with ITP was diagnosed. Steroid and immune gamma globulin therapy were successful in increasing the platelet count.Interestingly, human leukocyte antigen genotyping detected the alleles DQBI*0601 and DRBI*0803, which are related to both PBC and ITP in Japanese patients.This case suggests common immunogenetic factors might be involved in the development of PBC and ITP.