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报告双倍剂量雷公藤多甙治疗难治性肾病综合征１４例近期疗效观察。患者均服用雷公藤多甙２ｍｇ／ｋｇ·ｄ，治疗８周后，观察２４ｈ尿蛋白定量，肾功能变化及副反应。结果，４例获完全缓解（尿蛋白＜０．３ｇ／２４ｈ），４例获部分缓解（尿蛋白＜２．０ｇ／２４ｈ），６例无效。所有患者均能耐受双倍剂量雷公藤多甙，其中有２例ＡＬＴ升高，但不影响治疗。观察认为，双倍剂量雷公藤多甙对部分难治性肾病综合征有较好疗效。
Reported Double - dose Tripterygium Glycosides in Treatment of Refractory Nephrotic Syndrome in 14 Cases. Patients were taken Tripterygium glycosides 2mg / kg · d, 8 weeks after treatment, 24h urine protein quantitation, renal function changes and side effects. Four patients achieved complete remission (urinary protein <0.3g / 24h), partial remission in 4 patients (urinary protein <2.0g / 24h), and 6 were ineffective. All patients were able to tolerate double doses of tripterygium glycosides, including 2 cases of elevated ALT, but did not affect the treatment. Observation that the double dose of tripterygium glycosides on some refractory nephrotic syndrome have a good effect.