瘤型麻风动物模型脾脏T淋巴细胞的电镜观察

• 作 者: 王波 曹国玉 王道若 王远萍 杨果
• 机 构: 华西医大免疫研究室,华西医大免疫研究室,华西医大免疫研究室,华西医大电子显微镜室,华西医大电子显微镜室
• 出 处: 华西医科大学学报
• 发表日期: 1988年04期
• 关键词: 鼠麻风 瘤型麻风 鼠麻风杆菌 粗面内质网 T淋巴细胞 动物模型 空泡 超微结构 小鼠脾脏 核周隙

作者用透射电镜对鼠麻风杆菌(MLM)感染小鼠脾脏的T淋巴细胞作了观察。发现细胞的质膜变平坦,胞浆内线粒体明显肿胀,嵴变短,粗面内质网扩张,核周隙增宽,有些细胞的质膜及细胞器消失,仅留下一个固缩的细胞核。同时发现少数T淋巴细胞的胞浆中有MLM存在,邻近的质膜有缺损;胞浆中的细菌被质膜包裹,形成空泡,空泡内的细菌的结构已不太完整。

The author used transmission electron microscopy to observe the splenic T lymphocytes of mice infected with M. leprae (MLM). It was found that the plasma membrane of the cells became flat, the mitochondria in the cytoplasm were obviously swollen, the crests shortened, the rough endoplasmic reticulum expanded, the peritumoral space widened, and some plasma cells and organelles disappeared, leaving only a solidified nucleus. Also found that a small number of T lymphocytes in the cytoplasm of MLM exist, the adjacent plasma membrane defects; cytoplasmic bacteria are covered by the plasma membrane, the formation of vacuoles, vacuoles within the bacteria structure is not complete.