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苯为人类致癌物。尽管有关苯血液毒性的研究已深入到分子水平,但其机制尚未阐明,针对其表观遗传毒作用机制的研究更少。表观遗传是调节基因表达的主要机制之一,其改变主要表现为组蛋白乙酰化修饰、DNA甲基化和microRNA调控等,相关研究已成为生命科学研究的前沿和热点。沉默信息调节因子1(Silent information regulator 1,SIRT1)是烟酰胺腺嘌呤二核苷酸(Nicotinamide adenine dinucleotide,
Benzene is a human carcinogen. Although the research on the hematological toxicity of benzene has gone deep into the molecular level, its mechanism has not been elucidated yet there is less research on its mechanism of epigenetic toxicity. Epigenetics is one of the major mechanisms that regulate gene expression. The main alterations are histone acetylation, DNA methylation and microRNA regulation. Related research has become the frontier and hot point of life science research. Silent information regulator 1 (SIRT1) is a member of the family of Nicotinamide adenine dinucleotide