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目的探讨不同剂量阿托伐他汀对消退冠心病患者颈动脉斑块的影响。方法选取2013年1月—2014年1月在南方医科大学附属潮州中心医院心内科门诊治疗的76例冠心病颈动脉斑块患者,随机分为对照组和观察组,各38例。对照组采用低剂量阿托伐他汀(10mg/d)治疗,观察组采用高剂量阿托伐他汀(40mg/d)治疗,治疗6个月后比较两组患者的血脂水平、颈动脉内径、颈动脉内-中膜厚度(IMT)、斑块厚度等。结果治疗后观察组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、IMT均低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组,颈动脉内径较对照组增大,斑块厚度较对照组减小,差异有统计学意义(P<0.05)。结论高剂量阿托伐他汀对冠心病患者颈动脉斑块疗效较好,能有效降低血脂,减小斑块。
Objective To investigate the effect of different doses of atorvastatin on carotid plaque in patients with regression of coronary heart disease. Methods From January 2013 to January 2014, 76 patients with carotid plaque of coronary heart disease treated in Department of Cardiology, Chaozhou Central Hospital Affiliated to Southern Medical University were randomly divided into control group and observation group, with 38 cases in each group. The control group was treated with low dose atorvastatin (10mg / d), the observation group was treated with high dose of atorvastatin (40mg / d), and the blood lipid level, carotid artery diameter, neck Intima-media thickness (IMT), plaque thickness and the like. Results After treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and IMT in the observation group were lower than those in the control group, while the levels of high-density lipoprotein cholesterol (HDL- , The diameter of carotid artery increased compared with the control group, and the plaque thickness decreased compared with the control group, the difference was statistically significant (P <0.05). Conclusion High-dose atorvastatin has a good curative effect on carotid plaque in patients with coronary heart disease, which can effectively reduce blood lipid and reduce plaque.