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选取2013年1月至2014年12月住院老年的DM组40例、ACI组40例、DM+ACI组42例,老年健康者40例。结果 (1)TG、TC、LDL-C、Hb A1c、Cys-C、RBP4水平DM+ACI组患者的RBP4高于DM组、ACI组及对照组,差异有统计学意义(P<0.05);DM组和ACI组患者的的RBP4水平均高于对照组(P>0.05)。(2)血糖控制未达标(Hb A1c>7%)糖尿病患者的RBP4水平明显高于血糖控制良好(Hb A1c<7%)者,两者的差异有统计学意义(P<0.05)。(3)NIHSS评分>8的脑梗死患者血清RBP4水平明显高于评分<8的脑梗死患者,两者的差异有统计学意义(P<0.05)。(4)Spearman相关分析显示,血清TG、TC、LDL-C、Hb A1c的水平以及NIHSS评分与RBP4呈正相关。结论合并急性脑梗死患者RBP4水平明显升高,其与自身TG、TC、LDL-C、Hb A1c的水平以及NIHSS评分正相关;RBP4可作为老年糖尿病患者发生脑梗死的预测指标。
Forty patients with DM in hospitalized aged patients from January 2013 to December 2014 were selected, 40 patients in ACI group, 42 patients in DM + ACI group and 40 elderly healthy persons. Results (1) The levels of RBP4 in TG, TC, LDL-C, Hb A1c, Cys-C and RBP4 in DM + ACI group were significantly higher than those in DM group, ACI group and control group (P <0.05) The levels of RBP4 in DM group and ACI group were higher than those in control group (P> 0.05). (2) The level of RBP4 in patients with diabetes who did not meet the standard of glycemic control (Hb A1c> 7%) was significantly higher than those with good control of blood glucose (Hb A1c <7%), the difference was statistically significant (P <0.05). (3) Serum RBP4 level in patients with NIHSS score> 8 was significantly higher than that in patients with score <8 (P <0.05). (4) Spearman correlation analysis showed that serum TG, TC, LDL-C, Hb A1c levels and NIHSS score positively correlated with RBP4. Conclusions The level of RBP4 in patients with acute cerebral infarction is significantly increased, which is positively correlated with the level of TG, TC, LDL-C, Hb A1c and the NIHSS score. RBP4 can be used as a predictor of cerebral infarction in elderly patients with diabetes mellitus.