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采用ＳＰ免疫组织化学方法观察血管内皮生长因子（ＶＥＧＦ）在９４例肺癌组织的表达。结果显示，ＶＥＧＦ在肺癌组织表达的阳性率为７０．２％，明显高于癌旁正常组织。鳞癌和腺癌ＶＥＧＦ阳性组，其微血管计数值和增殖细胞栓抗原（ＰＣＮＡ）标记指数均高于阴性组。腺癌ＶＥＧＦ的表达与转移、分期和病理学分级等因素均无关；在鳞癌，有淋巴结转移组ＶＥＧＦ的阳性率高于无淋巴结转移组，Ⅲ～Ⅳ期癌高于Ⅰ～Ⅱ期癌。结果提示，ＶＥＧＦ表达与肺癌的发生有关，并能促进肺癌血管形成，使癌细胞的增殖活性升高。ＶＥＧＦ表达与肺鳞癌淋巴结转移和进展有关，可能是预后不良的标志
SP immunohistochemistry was used to observe the expression of vascular endothelial growth factor (VEGF) in 94 lung cancer tissues. The results showed that the positive rate of VEGF expression in lung cancer tissues was 70.2%, which was significantly higher than that of normal tissues adjacent to the cancer. In squamous cell carcinoma and adenocarcinoma VEGF positive groups, the microvessel counts and proliferation cell plug antigen (PCNA) markers were higher than those in the negative group. The expression of VEGF in adenocarcinoma was not related to factors such as metastasis, staging, and pathological grade. In squamous cell carcinoma, the positive rate of VEGF in lymph node metastasis group was higher than that in no lymph node metastasis group. The stage III to IV cancer was higher than stage I to II cancer. The results suggest that VEGF expression is associated with the occurrence of lung cancer and can promote angiogenesis in lung cancer and increase the proliferation activity of cancer cells. VEGF expression is associated with lymph node metastasis and progression in lung squamous cell carcinoma and may be a sign of poor prognosis.