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目的了解p53和血管内皮生长因子(vascular endothelial growth factor,VEGF)表达水平与肺癌临床病理特征之间的关系。方法采用免疫组化方法(二步法)检测220例肺癌组织中p53和VEGF的表达水平。结果 p53和VEGF的阳性表达率分别为48.6%和47.2%。p53和VEGF的表达水平与肺癌患者年龄、性别和组织学类型无相关性,P>0.05,与淋巴结转移、浸润和pTNM分期有关,P<0.05(P值分别为0.028、0.003和0.014),p53与原发肿瘤大小和癌细胞分化程度有关,P<0.05(P值分别为0.004和0.034),VEGF则与原发肿瘤大小和癌细胞分化程度无关,P>0.05(P值分别为0.798和0.686)。结论 p53和VEGF参与了肺癌的发生和发展过程,可以作为肺癌生物学水平的检测指标。
Objective To investigate the relationship between p53 and the expression of vascular endothelial growth factor (VEGF) and the clinicopathological features of lung cancer. Methods Immunohistochemistry (two-step method) was used to detect the expression of p53 and VEGF in 220 cases of lung cancer. Results The positive rates of p53 and VEGF were 48.6% and 47.2% respectively. The expression levels of p53 and VEGF were not correlated with the age, sex and histological type of lung cancer patients (P> 0.05), and were correlated with lymph node metastasis, infiltration and pTNM stage (P <0.05, P = 0.028,0.003 and 0.014, P <0.05 (P = 0.004 and 0.034, respectively). VEGF was not correlated with the size of primary tumor and the degree of differentiation of cancer cells (P> 0.05) (P = 0.798 and 0.686, respectively) ). Conclusions p53 and VEGF are involved in the occurrence and development of lung cancer, which can be used as a marker of lung cancer biological level.