Phylogeny of SARS-CoV as inferred from complete genome comparison

• 作 者: QI Zhen HU Yu LI Wei Chen Yanj
• 机 构: Institute of Biophysics,Institute of Computing Technology, Beijing Genomics Institute, Institute of
• 出 处: 科学通报
• 发表日期: 2004年期
• 关键词: SARS-associated coronavirus (SARS-CoV) coronavirus phylogeny infection relations
• 基金项目: 国家高技术研究发展计划(863计划);中国科学院知识创新工程项目

SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the genesis of SARS-CoV, the FDOD method previously developed by us was applied to comparing complete genomes from 12 SARS-CoV isolates to those from 12 previously identified coronaviruses and an unrooted phylogenetic tree was constructed. Our results show that all SARS-CoV isolates were clustered into a clique and previously identified coronaviruses formed the other clique. Meanwhile, the three groups of coronaviruses depart from each other clearly in our tree that is consistent with the results of prevenient papers. Differently, from the topology of the phylogenetic tree we found that SARS-CoV is more close to group 1 within genus coronavirus. The topology map also shows that the 12 SARS-CoV isolates may be divided into two groups determined by the association with the SARS-CoV from the Hotel M in Hong Kong that may give some information about the infectious relationship of the SARS.