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本文随机对照国产氟罗沙星、洛美沙星治疗细菌性感染８６例，每组各为４３例。氟罗沙星、洛美沙星的总有效率分别为８６％，７９％（Ｐ＞０．０５）。细菌清除率分别为７１．８％，７８．４％（Ｐ＞０．０５）、和不良反应（Ｐ＞０．０５）统计学上均无显著差异。氟罗沙星对绿脓杆菌的ＭＩＣ９０为２ｍｇ／１，ＡＵＣ４８．３ｍｇ·ｈ－１·Ｌ－１，凡已知致病菌为绿脓杆菌者，首选氟罗沙星，不用洛美沙星，本组绿脓杆菌５株，２／５株被清除，占４０％。虽不良反应和细菌清除率两组接近，因氟罗沙星对绿脓杆菌清除有一定作用，此点氟罗沙星优于洛美沙星。氟罗沙星、洛美沙星抗菌谱广、口服吸收好，不良反应少，对轻、中度呼吸道感染、肠道及泌尿道感染有良好疗效。
This randomized controlled domestic fleroxacin, Lomefloxacin treatment of bacterial infections in 86 cases, each of 43 cases. The total effective rates of fleroxacin and lomefloxacin were 86% and 79%, respectively (P> 0.05). The bacterial clearance rates were 71.8% and 78.4% respectively (P> 0.05), but no significant differences were found between them and adverse reactions (P> 0.05). The MIC90 of fleroxacin against Pseudomonas aeruginosa is 2mg / 1, AUC48.3mg · h-1 · L-1. Those who are known to be Pseudomonas aeruginosa are the first choice of fleroxacin, 5 strains of bacilli, 2/5 strains were removed, accounting for 40%. Although the adverse reactions and bacterial clearance rate of two groups close, due to fleroxacin cleared of Pseudomonas aeruginosa have a role, this point is better than flossarfloxacin Lomefloxacin. Fleroxacin, Lomefloxacin antibacterial spectrum wide, good oral absorption, fewer adverse reactions, mild to moderate respiratory tract infections, intestinal and urinary tract infections have a good effect.