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目的:观察附子理中汤加减联合莫沙必利治疗糖尿病胃轻瘫(DGP)的临床疗效。方法:将90例DGP患者按随机法分为对照组和观察组,每组45例。两组患者均给予糖尿病基础治疗,在此基础上对照组患者给予莫沙必利治疗,观察组患者给予附子理中汤联合莫沙必利治疗,观察比较两组临床疗效,两组治疗前后胃排空时间,同时观察停药1个月及3个月后复发情况。结果:观察组治疗总有效率为91.11%,明显优于对照组的(68.89%),差异有统计学意义(P<0.05)。治疗前,两组患者胃排空时间比较差异无统计学意义(P>0.05);治疗后,两组患者胃排空时间较治疗前均明显缩短,且观察组较对照组胃排空时间缩短更显著,差异有统计学意义(P<0.05)。停药1个月后,观察组未见复发,对照组复发3例,两组复发率比较差异无统计学意义(P>0.05);停药3个月后,观察组复发1例,对照组复发9例,观察复发率明显低于对照组(P<0.05)。结论:附子理中汤联合莫沙必利治疗DGP明显缩短胃排空时间,提高治疗有效率,降低复发率,具有较高临床应用价值。
Objective: To observe the curative effect of Fuzi Lizhong Decoction combined with mosapride on diabetic gastroparesis (DGP). Methods: 90 cases of DGP patients were randomly divided into control group and observation group, 45 cases in each group. Two groups of patients were given basic diabetes treatment, on the basis of the control group patients were given mosapride treatment, the observation group were given Fuzi Li Zhong Tang combined with mosapride treatment, the clinical efficacy of the two groups were observed and compared, the two groups before and after treatment of stomach Emptying time, at the same time observe withdrawal 1 month and 3 months after the recurrence. Results: The total effective rate of the observation group was 91.11%, which was significantly better than that of the control group (68.89%), the difference was statistically significant (P <0.05). Before treatment, there was no significant difference in gastric emptying time between the two groups (P> 0.05). After treatment, the gastric emptying time in both groups was significantly shorter than before treatment, and the gastric emptying time in the observation group was shorter than that in the control group More significant, the difference was statistically significant (P <0.05). One month after discontinuation, there was no recurrence in the observation group and 3 cases in the control group. There was no significant difference in relapse rate between the two groups (P> 0.05) Recurrence in 9 cases, the recurrence rate was significantly lower than the control group (P <0.05). Conclusion: Aconite decoction combined with mosapride treatment of DGP significantly shortened gastric emptying time and improve the treatment efficiency, reduce the recurrence rate, with high clinical value.