Childhood body mass index and adult ischemic stroke

• 出 处: 中华物理医学与康复杂志
• 发表日期: 2018年40期

BACKGROUND AND OBJECTIVE

Ischemic stroke (IS) is a major cause of death and disability worldwide. Studies investigating the association between childhood body mass index (BMI) and adult IS have produced inconsistent results. This study was designed to better understand this relationship.

METHODS

Data for this study were retrieved from the Copenhagen School Health Records Register, including information for 372，636 children born from 1930 to 1989, with follow-up conducted using the National Health Registers through 2012. From records of physical examinations, BMI data were calculated. Data were included for adults at least 25 years of age at study entry, with follow-up ending on the date of a first ever IS, death or study completion on December 31, 2012.

RESULTS

Of the 307，677 individuals followed, no association was found between childhood BMI and risk of IS after 55 years of age. However, an association was found between early occurring IS and BMI at ages seven to 13. Using the BMI at age 13 of 16.7-17.9 kg/m² as a reference, the hazard ratios (HR) for early ischemic stroke were 1.71 for females with a BMI of greater than 23.3 kg/m^2, and 1.77 for a BMI of greater than 22.5 kg/m² in males. In addition, an increase in BMI between ages seven and 13 was associated with an increased risk of early IS in both males and females (HR 1.10 and 1.14, respectively).

CONCLUSION

This large Danish study found that childhood obesity at age 13, as well as increasing obesity between ages seven and 13, are associated with an increased risk of early ischemic stroke.