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目的探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效及不良反应。方法选取2014年7月-2015年6月该院收治的异位妊娠患者80例为研究对象,随机分为对照组和观察组,每组各40例。对照组给予单一的甲氨蝶呤治疗,观察组给予甲氨蝶呤联合米非司酮治疗。对比两组患者的治疗成功率、治疗前后血β-h CG值和包块直径变化情况、包块消失时间、住院时间、不良反应发生率。结果观察组的治疗成功率高于对照组(P<0.05)。治疗后,两组患者的血β-h CG值、包块直径均明显小于治疗前(P<0.05);观察组的血β-h CG值、包块直径均小于对照组,包块消失时间、住院时间均明显短于对照组,差异均有统计学意义(P<0.05);观察组的不良反应发生率略高于对照组,但差异无统计学意义(P>0.05)。结论在异位妊娠的临床治疗中,采用甲氨蝶呤与米非司酮联合治疗具有显著的疗效,具有起效快、不良反应少的优点。
Objective To investigate the clinical efficacy and side effects of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods Totally 80 patients with ectopic pregnancy admitted to our hospital from July 2014 to June 2015 were randomly divided into control group and observation group, 40 cases in each group. The control group received a single methotrexate treatment, the observation group was given methotrexate combined with mifepristone treatment. The success rate of treatment was compared between the two groups. The change of β-h CG value and mass diameter before and after treatment, disappearance of mass, hospitalization time and the incidence of adverse reactions were compared. Results The success rate of treatment in observation group was higher than that in control group (P <0.05). After treatment, the blood β-h CG values and mass diameter of the two groups were significantly lower than those before treatment (P <0.05); the β-h CG values and mass diameter of the observation group were less than those of the control group, (P0.05). The incidence of adverse reactions in the observation group was slightly higher than that in the control group, but the difference was not statistically significant (P> 0.05). Conclusion In the clinical treatment of ectopic pregnancy, methotrexate combined with mifepristone has a significant effect, with fast onset, fewer adverse reactions.