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目的:观察金龙胶囊联合化疗与单纯化疗对晚期肺小细胞癌患者的疗效、生活质量等因素的影响。方法:将99例患有晚期非小细胞肺癌患者随机分为两组:治疗组,在NP化疗方案基础上加服金龙胶囊治疗;对照组,单纯接受NP方案化疗。对99例患者追踪2个月,观察并比较患者的疗效、体质量、生活质量、毒副反应等方面的差异。结果:在NP化疗方案基础上加服金龙胶囊治疗在患者疗效评价方面与单纯NP方案化疗相比不具有统计学差异(P>0.05);在提高患者体质量、改善患者临床症状和生活质量等方面均优于单纯NP方案化疗(P<0.05);在化疗所引发的白细胞、血红蛋白和血小板降低等部分毒副反应发生率方面低于单纯NP方案化疗组(P<0.05)。结论:金龙胶囊联合NP化疗治疗晚期非小细胞肺癌不仅可以起到化疗增效的作用,而且能够明显提高患者生活质量,有效的改善临床症候,降低化疗引发的毒副反应,这一联合治疗方案可以在临床治疗中广泛推广。
Objective: To observe the effects of Jinlong Capsule combined with chemotherapy and chemotherapy alone on the efficacy and quality of life in patients with advanced small cell lung cancer. Methods: Ninety-nine patients with advanced non-small cell lung cancer were randomly divided into two groups: treatment group treated with Jinlong Capsule on the basis of NP chemotherapy regimen, and control group received NP chemotherapy alone. Ninety-two patients were followed up for 2 months. The curative effect, body mass, quality of life, and side effects of the patients were observed and compared. Results: The addition of Jinlong Capsule on the basis of NP chemotherapy regimen showed no significant difference (P> 0.05) in the evaluation of the curative effect between patients and NP regimen alone. The improvement of body weight, improvement of clinical symptoms (P <0.05). The incidence of toxic and side effects of chemotherapy-induced leukopenia, hemoglobin and thrombocytopenia were lower than those of NP chemotherapy alone (P <0.05). Conclusion: Jinlong Capsule combined with NP chemotherapy for advanced non-small cell lung cancer can not only play the role of chemotherapy synergies, but also can significantly improve the quality of life of patients, effectively improve the clinical symptoms and reduce chemotherapy-induced side effects, the combination therapy Can be widely promoted in clinical treatment.