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目的探讨细胞色素P450芳香化酶(cytochrome P450 family 19 subfamily A member 1,CYP19A1)基因rs10046位点(C>T)多态性与乳腺癌易感性的关系。方法计算机检索PubMed、Embase、中国期刊全文数据库(China National Knowledge Infranstructure,CNKI)、维普科技期刊全文数据库、万方数据知识服务平台等中英文数据库,获取关于CYP19A1基因多态性与乳腺癌易感性的研究结果。采用Stata 11.1软件对各项原始研究结果进行Meta分析,计算合并OR值及95%可信区间,并评估发表偏倚。结果共纳入15项病例对照研究,其中乳腺癌病例组9241人,对照组12 681人。Meta分析结果显示CYP19A1基因rs10046位点(C>T)多态性与乳腺癌的发生风险无统计学差异(P>0.05)。(Tvs.C模型:OR=0.929,95%CI为0.778~1.110,P=0.420;TT vs.CC模型:OR=0.902,95%CI为0.671~1.211,P=0.492;TCvs.CC模型:OR=0.996,95%CI为0.929~1.067,P=0.909;TT+TCvs.CC模型:OR=0.934,95%CI为0.784~1.112,P=0.442;TTvs.CC+TC模型:OR=0.920,95%CI为0.699~1.209,P=0.548),民族、对照组来源、文献质量评分高低的分层分析,亦显示相同的结果。结论 CYP19A1基因rs10046位点(C>T)多态性与乳腺癌的发生风险无明显相关。
Objective To investigate the relationship between rs10046 (C> T) polymorphism of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) gene and breast cancer susceptibility. Methods Chinese and English databases such as PubMed, Embase, China National Knowledge Infrastructure (CNKI), VIP database, Wanfang data knowledge service platform were searched in order to obtain information about CYP19A1 polymorphism and breast cancer susceptibility Research result. Stata 11.1 software was used to perform meta-analysis of the original findings, and the combined OR and 95% confidence intervals were calculated and publication bias assessed. Results A total of 15 case-control studies were included, of which 9241 cases were breast cancer cases and 12 681 cases in the control group. The results of Meta analysis showed that the rs10046 polymorphism of CYP19A1 gene was not associated with the risk of breast cancer (P> 0.05). (Tvs.C model: OR = 0.929, 95% CI 0.778-1.110, P = 0.420; TT vs.CC model: OR = 0.902, 95% CI 0.671-1.211, P = 0.492; = 0.996, 95% CI 0.929-1.067, P = 0.909; TT + TCvs.CC model: OR = 0.934, 95% CI 0.784-1 1.112, P = 0.442; TTvs.CC + TC model: OR = 0.920, 95 % CI was 0.699-1.209, P = 0.548). The stratified analysis of ethnic origin, control group and quality of literatures also showed the same result. Conclusion CYP19A1 rs10046 locus (C> T) polymorphism and breast cancer risk was not significantly correlated.