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炎痛喜康系新的非甾体消炎镇痛药(NSAID),有明显的抗炎作用,具有服药量小(日仅20毫克)、维持时间长(人的血浆半衰期为36～45小时)、毒性小的优点。临床主要用于类风湿性关节炎、风湿性关节炎、骨关节炎、关节粘连性脊椎炎等。炎痛喜康属强力抗炎镇痛药,和其它非甾体药物一样,对胃肠道有刺激,可引起溃疡、消化道大出血及穿孔。现将炎痛喜康的不良反应,结合临床观察到的24例报告如下: 一、上消化道出血本组有10例。炎痛喜康致上消化道出血前多数无明显消化道症状,少数有上腹部不适、头晕、心慌、乏力逐渐加重、排柏油样便,后有呕血。多数呈失血性休克而就诊。目前认为许多NSAID对前列腺合成酶有抑制作用,使胃粘膜血管前列腺素的合成减少,血管舒张作
Yikongxi Kang new non-steroidal anti-inflammatory analgesics (NSAID), a significant anti-inflammatory effect, with a small dose (only 20 mg day), to maintain a long time (human plasma half-life of 36 to 45 hours) , The advantages of small toxicity. Clinical mainly for rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, joint spondylitis and so on. Inflammation is a potent anti-inflammatory analgesic and, like other non-steroidal drugs, it irritates the gastrointestinal tract and can cause ulcers, hemorrhage and perforation of the digestive tract. Now inflammatory Yikang adverse reactions, combined with the clinical observation of 24 cases reported as follows: First, the upper gastrointestinal bleeding in this group of 10 patients. Inflammatory pain Xikang induced gastrointestinal bleeding before the majority of no obvious gastrointestinal symptoms, a few have upper abdominal discomfort, dizziness, palpitation, fatigue gradually increased, ascending tarry stool, after vomiting. The majority of hemorrhagic shock and treatment. At present, many NSAID inhibition of prostate synthase, reducing the synthesis of vascular prostaglandins, vasodilation