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〔目的〕了解机体用肾综合征出血热 (HFRS)灭活疫苗免疫后的抗体应答水平和疫苗之间的交叉免疫反应水平。〔方法〕对 2 0 6名健康人用肾综合征出血热双价灭活疫苗进行基础免疫 ,1年后分别用双价灭活疫苗和I、Ⅱ型单价灭活疫苗进行加强免疫 ,并连续观察机体两年的IgC抗体和中和抗体的免疫应答反应情况。〔结果〕①基础免疫后 2周IgG抗体的阳转率为 96.76%,GMT为 3 8.0 5 ;1年后阳转率降为 5 1.91%,GMT为 2 5 .45 ;用不同剂型疫苗加强免疫后 2周 ,三组的阳转率分别提升为 98.46%、10 0 %、98.0 3 %,GMT分别为 3 8.0 2、43 .84和 3 4.82 ;加强免疫后 1年 ,三组的阳转率保持在 83 .82 %、78.5 7%、75 .0 0 %,GMT分别为 40 .2 1、42 .0 5和 3 3 .75。②基础免疫后 2周中和抗体的阳转率I、Ⅱ型分别为 10 0 %、92 .5 0 %,GMT分别为 2 0 .82、15 .66;1年后阳转率降为 5 5 .81%、46.5 1%,GMT为 5 .45和 5 .18;用不同剂型疫苗加强免疫后 2周 ,三组的阳转率I、Ⅱ型都达到 10 0 %,三组的GMTI、Ⅱ型分别为 2 0 .0 1、2 0 .0 0 / 46.66、19.99/ 12 .42、16.82 ;加强免疫后 1年 ,三组的阳转率I、Ⅱ型分别为 86.67%、10 0 .0 0 %/ 10 0 %、90 %/ 76.47%、75 .3 0 %,GMTI、Ⅱ型分别为 14 .5 2、6.60 / 12 .3 1、5 .83 / 1
[Objective] To understand the level of antibody response after immunization with the inactivated HFRS vaccine and the level of cross-immunization among the vaccines. [Methods] Two hundred and six healthy individuals were immunized with the dual-inactivated vaccine of hemorrhagic fever with renal syndrome, and one year later, they were boosted with bivalent inactivated vaccine and monovalent inactivated vaccine of type I and type II, respectively Observed two-year body IgC antibodies and neutralizing antibodies in immune response. Results ① The positive rate of IgG antibody was 96.76% and the GMT was 3 8.05 two weeks after the basic immunization. The positive rate of one year later decreased to 5.91% and the GMT was 25.545. Immunization with different dosage forms of vaccine After 2 weeks, the positive conversion rates of the three groups increased to 98.46%, 100% and 98.0%, respectively, with the GMTs of 3 8.0, 2.43 and 4.42, respectively. After one year of booster immunization, Maintained at 83.82%, 78.57%, 75.0% and GMT of 40.21, 1.42.5 and 33.375, respectively. ② The positive rate of neutralizing antibody in type I and type II was 100% and 92.5% respectively at 2 weeks after basal immunization, the GMT was 20.82 and 15.66, respectively, and the positive rate was reduced to 5 5 .81%, 46.5% and GMTs of 5.45 and 5.18 respectively. After two weeks of immunization with different dosage forms of vaccine, the positive rate of type I and type II in all three groups reached 100%. The GMTI, Ⅱ type were 20.012.000 / 46.66,19.99 / 12.42,16.82; 1 year after booster immunization, the positive rate of the three groups was 86.67%, 100%. 0 0% / 10 0%, 90% / 76.47%, 75.3%, GMTI, and Ⅱ were 14.5, 2.6.6 / 12.3, 1.5.83 / 1