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目的总结小儿血小板减少性紫癜(ITP)的临床特点,其发生与病毒感染的关系及治疗。方法对44例ITP患者的临床资料进行回顾性分析。结果急性占68.2%,慢性占31.8%;男女比例为1.75∶1;PAIgG升高占75%,PAIgA升高占5%;发病1～6周前有明确前驱感染者24例(54.5%);检测到巨细胞病毒(CMV)、EB病毒(EBV)、人微小病毒B19感染急性病例5例(16.7%),慢性病例11例(78.6%);在传统治疗方法外,采用更昔洛韦(丽科伟)清除病毒感染,急性患者全部治愈,慢性患者疗效提高。结论血小板减少性紫癜,特别是慢性病例的发生与病毒感染密切相关;采用更昔洛韦清除病毒,可提高疗效。
Objective To summarize the clinical features of pediatric thrombocytopenic purpura (ITP), its relationship with viral infection and its treatment. Methods The clinical data of 44 patients with ITP were retrospectively analyzed. Results Acute 68.2%, chronic 31.8%; male to female ratio was 1.75: 1; PAIgG increased 75%, PAIgA increased 5%; 1 to 6 weeks before the onset of clear precursor infection in 24 patients (54.5%); 5 cases (16.7%) were acute cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human parvovirus B19 infection, and 11 cases (78.6%) were chronic chronic bronchitis virus. In addition to the traditional treatment methods, Li Kewei) clear the virus infection, all acute patients were cured, improved efficacy of chronic patients. Conclusions The occurrence of thrombocytopenic purpura, especially chronic cases, is closely related to the virus infection. Using ganciclovir to eliminate the virus can improve the curative effect.