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目的 探讨移植条件不完全理想的疑难病例,进行异基因骨髓移植的方法。方法 2例急性粒细胞白血病患者与骨髓供者的血型不同,其中1例为父子间骨髓移植的特殊病例;另1例急性淋巴细胞白血病患者,第三次白血病复发,肺功能异常。患者按环磷酰胺加全身照射预处理,血型不同的供者骨髓,采用离心法分离血浆。结果3例患者异基因骨髓移植成功,2例生存期超过半年。结论 尽管异基因骨髓移植难度大、要求高,但是经过周密计划、精心治疗,仍能成功地进行疑难病例的异基因骨髓移植。
Objective To explore the method of allogeneic bone marrow transplantation for the difficult cases with imperfect transplant conditions. Methods Two cases of acute myelogenous leukemia patients and bone marrow donors had different blood types. One of them was a special case of bone marrow transplantation between father and son. Another patient with acute lymphoblastic leukemia had a third leukemia recurrence and abnormal lung function. The patients were pretreated with cyclophosphamide plus whole body irradiation. The bone marrow of donors with different blood types was used to separate plasma by centrifugation. Results Allogeneic bone marrow transplantation was successful in 3 patients, and 2 patients survived more than half a year. Conclusion Although allogeneic bone marrow transplantation is difficult and demanding, after careful planning and careful treatment, allogeneic bone marrow transplantation in difficult cases can still be successfully performed.