木尘与肠癌的回顾性队列研究

• 作 者: 杨跃林 王绵珍 王治明 詹承烈
• 机 构: 华西医科大学职业病防治院
• 出 处: 中国公共卫生学报
• 发表日期: 1998年05期
• 关键词: 木尘 回顾性队列研究 暴露组 年龄别死亡率 标化死亡率 有毒有害因素 接尘 职业接触 显著性差异 标化死亡比

用回顾性队列研究方法，暴露组为四川某木材综合厂工龄１年以上的接触木尘职工２３６２（男１７０７，女６５５）人，观察期１５年（１９７８．１．１至１９９２．１２．３１），观察了３３６７９人年。非暴露组为当地某煤矿工龄１年以上男性职工２５８７人，观察期２１年（１９７２．１．１至１９９２．１２．３１），观察了５４０４０人年。结果显示接触木尘职工肠癌的标化死亡率４３７８／１０５（ＲＲ４０８，Ｐ＜００１）。与当地居民死亡率比较，接尘职工肠癌的ＳＭＲ为２７２１（９５％ＣＩ１３６～４８７，Ｐ＜００１）。ＳＰＭＲ为３１４４，有高度显著性差异（Ｐ＜００１）。提示木尘可能与肠癌有关

A retrospective cohort study was conducted in which exposure groups were 2362 (male 1707, female 655) workers with a work-age of more than 1 year in a timber comprehensive factory in Sichuan for 15 years (from 1978.1.1 to 1992.12.31 ), Observed 33,679 person-years. The non-exposed group was 2587 male workers with a work-age of more than one year in a local coal mine. The observation period was 21 years (from January 1972 to January 1992, December 31), and 54040 person-years were observed. The result showed that the standardized death rate of intestinal cancer patients exposed to wood dust was 4378 / 105 (RR408, P <001). Compared with the local residents’ mortality rate, the SMR of workers exposed to dust was 2721 (95% CI 136 ~ 487, P <001). The SPMR was 3144, with a highly significant difference (P <001). Tip wood dust may be related to bowel cancer