论文部分内容阅读
层粘连蛋白是细胞外间质非胶原糖蛋白。其功能与纤维连接蛋白及软骨连接蛋白类似,是细胞粘着于基质的介质,并连接基质中的大分子物质。同时具有许多生物学活性,调节细胞的生长、分化;在肝纤维化的形成过程中可能起着一定的调控作用。另外,与肿瘤的浸润转移有关。近年临床观察发现其血清浓度能反映肝纤维化及门静脉高压的程度,是慢性肝病、肝纤维化诊断中一个新的、有价值的血清学指标。
Laminin is an extracellular matrix non-collagen glycoprotein. Its function is similar to fibronectin and chondro-junction protein, which is a medium in which cells adhere to a matrix and connects with macromolecular substances in the matrix. At the same time, it has many biological activities and regulates the growth and differentiation of cells. It may play a regulatory role in the formation of hepatic fibrosis. In addition, with the invasion and metastasis of the tumor. In recent years, clinical observation found that the serum concentration can reflect the degree of liver fibrosis and portal hypertension, chronic liver disease, liver fibrosis diagnosis of a new, valuable serological indicators.