【摘 要】
：
Background Neuroimaging techniques provide rich and accurate measures of brain structure and function,and have become one of the most popular methods in mental health and neuroscience research.Rapidly growing neuroimaging research generates massive amount
【机 构】
：
Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Jing H
论文部分内容阅读
Background Neuroimaging techniques provide rich and accurate measures of brain structure and function,and have become one of the most popular methods in mental health and neuroscience research.Rapidly growing neuroimaging research generates massive amounts of data,bringing new challenges in data collection,large-scale data management,efficient computing requirements and data mining and analyses.Aims To tackle the challenges and promote the application of neuroimaging technology in clinical practice,we developed an integrated neuroimaging cloud(INCloud).INCloud provides a full-stack solution for the entire process of large-scale neuroimaging data collection,management,analysis and clinical applications.Methods INCloud consists of data acquisition systems,a data warehouse,automatic multimodal image quality check and processing systems,a brain feature library,a high-performance computing cluster and computer-aided diagnosis systems(CADS)for mental disorders.A unique design of INCloud is the brain feature library that converts the unit of data management from image to image features such as hippocampal volume.Connecting the CADS to the scientific database,INCloud allows the accumulation of scientific data to continuously improve the accuracy of objective diagnosis of mental disorders.Results Users can manage and analyze neuroimaging data on INCloud,without the need to download them to the local device.INCloud users can query,manage,analyze and share image features based on customized criteria.Several examples of\'mega-analyses\'based on the brain feature library are shown.Conclusions Compared with traditional neuroimaging acquisition and analysis workflow,INCloud features safe and convenient data management and sharing,reduced technical requirements for researchers,high-efficiency computing and data mining,and straightforward translations to clinical service.The design and implementation of the system are also applicable to imaging research platforms in other fields.
其他文献
《世界反兴奋剂条例》条款2.1和2.2规定:认定兴奋剂违规时,无需证明运动员的意图、过错、疏忽或明知使用;换言之,认定兴奋剂违规不需要考虑行为人是否具有主观过错.由此,普遍认为兴奋剂违规归责秉承“严格责任”原则.但《世界反兴奋剂条例》将条款2.5中的“篡改”定义为故意行为,行为人具有主观故意是构成条款2.5下兴奋剂违规必不可少的要件,在认定违规时必须予以考虑,致使严格责任与条款2.5发生冲突.分析条款2.5的目的、构成要件以及适用实践,将其确定为“过错责任”或更为恰当,严格责任也因此表现出被逐步限制的趋势
退休以后,忙的也忘了看看脸,无情岁月催人老,土埋半截的老人,有啥好看的.多年后的一天,忽然来了精神头,有了想照镜子的好奇心.真照了,却被吓了一跳.镜面里的我,还真是变了模样:肿眼袋消失了,眼角的皱纹平滑了,目光也有精神了;舌下的两根粗血管,也在不觉中由紫变红,管中的鲜血如同溪流般清澈;过去稀疏的眉毛,变得浓黑而厚重,闪动着活力的光芒,内心瞬间便涌起一股激情;最露脸的,就是腮帮长肉了,面庞红润了,轮廓年轻了,映照出一副令人惊诧的新面孔.这是自己的脸吗?不敢相信.
近年来,一些不法分子瞄准老年人这一特殊的弱势群体,“发明”了多种手段、方法和方式,对老年群体进行钱财诈骗,致使许多老年人“中枪”受骗.老年人不仅要增强防骗识诈的能力,更要提升自我保护意识,不给自己的晚年生活留下一丝一毫的阴影、伤害和遗憾.
中国强调发展实体经济有一个背景,就是这几年所谓的“虚拟经济”出现了一些问题.首先是过度的金融化,比如,房地产被作为投资品过度炒作,背离了“房子是用来住的,不是用来炒的”的基本属性.其次,有些金融活动过度的自我循环,或者叫内卷,比如,难以穿透、掩盖风险的次贷产品,有些活动实际还演变成“庞氏骗局”.
帕金森病很常见的问题就是步态障碍,表现为行走缓慢、小碎步、慌张步态等,其中最具致残性的就是冻结步态.试想一下,走着走着,突然就被冻在原地,那会怎样?根据物理学的原理,脚停住了,身体由于惯性还会继续向前移动,于是,跌倒发生了.这也就是为什么冻结步态是帕金森患者致残的重要原因.
我国目前65岁及以上人群已近2亿,且人口老龄化已进入快速发展阶段,老年人口平均每年增加800万～ 900万人,预计2050年我国老年人口将达到3.9亿,约占总人口的1/4.随着人口老龄化进程加快,老年患者日益增多,各种安全、健康问题接踵而至.其中,跌倒已是我国65岁以上老年人意外伤害死亡的首位原因.
In clinical development,adequate and well-controlled randomised clinical trials are usually conducted to evaluate the safety and efficacy of test treatment under investigation.The purpose is to ensure that there is an accurate and reliable assessment of t
Background Substantial variations in the prevalences of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of
Background The corpus callosum(CC)is the most targeted region in the cerebrum that integrates cognitive data between homologous areas in the right and left hemispheres.Aims Our study used statistical analysis to determine whether there was a correlation b
Background Obsessive-compulsive disorder(OCD)is considered a very debilitating disorder with severe loss of quality of life and income.Aims This study estimates the quality of life and economic consequences of OCD in China.Methods The research team interv