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目的对比研究斜视性弱视不同注视性质患者多焦视觉诱发电位特征性变化,探讨弱视发病机制。方法采用德国Roland公司的RETIscan3.15多焦视觉电生理仪,提取FOK(一阶反应)。共记录和分析了不同注视性质斜视性弱视儿童52眼(中心凹型26眼;黄斑型21眼;黄斑周围型5眼),并与正常注视性质对照组儿童(60眼)作比较。结果斜视性弱视眼:中心凹注视眼图形中央区振幅下降陡峭,潜伏期最长。随离心度加大,周边区振幅下降平缓;黄斑注视眼中央区振幅下降平缓,潜伏期减小。随离心度加大,周边区振幅逐步下降;黄斑周围注视眼图形杂乱,中心至周边一侧可见多个小的异常波峰隆起,呈不对称分布。黄斑型注视组与黄斑周围型注视组在不同离心度mfVEP反应无统计学差异。结论虽然旁中心注视眼mfVEP不能反映视网膜中心区真实机能,但是异常网膜对应区域受到的抑制还是重于周边区域。
Objective To compare the characteristic changes of multifocal visual evoked potentials in patients with strabismic amblyopia with different gaze, and to explore the pathogenesis of amblyopia. Methods The RETIscan3.15 multifocal visual electrophysiologist from Roland Company of Germany was used to extract FOK (first order reaction). A total of 52 eyes with strabismic amblyopia (26 with foveola, 21 with macular and 5 with macular) were recorded and analyzed and compared with those in normal gaze control group (60 eyes). Results Strabismic amblyopia: The central area of the fovea in the fovea dropped steeply with the longest incubation period. With the increase of eccentricity, the amplitude of the surrounding area decreased gently; the amplitude of the central area of the macular gaze decreased gently and the latency decreased. With the increase of eccentricity, the amplitude of the surrounding area gradually decreased; the pattern of macular gazes around the macula was disorderly, and a few small anomalous peaks were observed from the center to the peripheral side, showing an asymmetrical distribution. There was no significant difference in the mfVEP response between the macular type gazing group and the macular gazing group at different degrees of eccentricity. Conclusion Although mfVEP can not reflect the true central function of the retina, it is more important than the peripheral area to suppress the corresponding area of the abnormal retina.