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为探讨一氧化氮合成酶（ＮＯＳ）在十二指肠溃疡（ＤＵ）的变化及其意义，我们观察了２９例幽门螺杆菌（ＨＰ）阳性的活动期ＤＵ患者。在抗ＨＰ治疗前后的胃粘膜ＮＯＳ活性及空腹血清胃泌素浓度的变化，并与１２例非溃疡性消化不良患者进行比较，结果显示：活动期ＤＵ患者胃粘膜ＮＯＳ活性及血清胃泌素浓度明显高于抗ＨＰ治疗后的愈合期ＤＵ患者（Ｐ＜０．００１和Ｐ＜０．０５）．愈合期ＤＵ患者胃粘膜ＮＯＳ活性及胃泌素浓度与对照组无显著差异（Ｐ＞０．０５）：ＨＰ根除者与未根除者ＮＯＳ变化无明显差异（Ｐ＞０．０５）．而胃泌素浓度在ＨＰ根除者明显下降（Ｐ＜０．００１）。提示：活动期ＤＵ患者ＮＯＳ活性升高可能具有调节胃泌素分泌而有益于溃疡愈合。
To investigate the significance and significance of nitric oxide synthase (NOS) in duodenal ulcer (DU), we observed 29 patients with active H. pylori (HP) positive DU. The changes of gastric mucosal NOS activity and fasting serum gastrin concentration before and after anti-HP treatment were compared with 12 non-ulcer dyspeptic patients. The results showed that gastric mucosal NOS activity and serum gastrin concentration Was significantly higher than that of patients with DU during healing after anti-HP treatment (P <0.001 and P <0.05). Gastric mucosal NOS activity and gastrin concentration in DU patients during healing phase were not significantly different from those in control group (P> 0.05). There was no significant difference in NOS between HP eradication and non-eradication patients (P> 0.05). Gastrin concentration was significantly lower in HP eradication (P <0.001). Tip: Active DU patients with elevated activity of NOS may have to regulate the secretion of gastrin beneficial ulcer healing.