论文部分内容阅读
目的了解西地那非不同剂量对新生儿持续肺动脉高压的治疗效果。方法在排除需要吸入NO的患儿后对40例按不同剂量(0.25,0.5,1.0,2.0mg/kg)分组,每24h检测一次SPO2、PaO2、PaCO2、pH值、PAP,最后再进行对比分析。结果发现西地那非可以改善肺功能,纠正缺氧,同时随着剂量的增加,疗效更明显,但不良反应发生率也升高。结论西地那非可有效治疗新生儿持续肺动脉高压,但需注意高剂量下的不良反应。
Objective To investigate the effects of different doses of sildenafil on neonatal persistent pulmonary hypertension. Methods After excluding children with NO inhalation, 40 patients were divided into groups according to different doses (0.25, 0.5, 1.0, 2.0 mg / kg), and SPO2, PaO2, PaCO2, pH and PAP were measured every 24h and then compared with each other . The results showed that sildenafil can improve lung function, correct hypoxia, with the dose increased, the effect is more obvious, but the incidence of adverse reactions also increased. Conclusion Sildenafil can effectively treat persistent pulmonary hypertension in newborns, but pay attention to adverse reactions in high doses.