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目的分析慢性脑供血不足患者血清同型半胱氨酸(Hcy)与颈动脉硬化的关系。方法 38例慢性脑供血不足患者作为观察组,选取同期体检健康者36例作为对照组,比较两组血清Hcy水平,分析观察组血清Hcy与颈动脉硬化的关系。结果观察组患者血清Hcy(18.2±3.6)μmol/L明显高于对照组的(10.7±3.4)μmol/L,差异具有统计学意义(P<0.05);颈部血管彩色超声检查显示,38例观察组患者中20例(52.6%)有颈动脉粥样硬化斑块。按照有无颈动脉粥样硬化斑块分组,20例有颈动脉粥样硬化斑块的患者血清Hcy(21.3±3.8)μmol/L,18例无颈动脉粥样硬化斑块的患者血清Hcy为(14.1±4.0)μmol/L,两组比较差异具有统计学意义(t=5.689,P=0.000<0.05)。结论血清Hcy与慢性脑供血不足患者颈动脉硬化之间关系密切,可能对脑卒中风险有预示作用。
Objective To analyze the relationship between serum homocysteine (Hcy) and carotid atherosclerosis in patients with chronic cerebral insufficiency. Methods Thirty-eight patients with chronic cerebral hypoperfusion were selected as the observation group. 36 healthy subjects were selected as the control group. The serum Hcy levels were compared between the two groups. The relationship between serum Hcy and carotid atherosclerosis in the observation group was analyzed. Results The Hcy in the observation group (18.2 ± 3.6) μmol / L was significantly higher than that in the control group (10.7 ± 3.4) μmol / L, the difference was statistically significant (P <0.05) Twenty patients (52.6%) in the observation group had carotid atherosclerotic plaques. According to the presence or absence of carotid atherosclerotic plaque, the serum Hcy (21.3 ± 3.8) μmol / L in 20 patients with carotid atherosclerosis and 18 patients without carotid atherosclerosis (14.1 ± 4.0) μmol / L, the difference between the two groups was statistically significant (t = 5.689, P = 0.000 <0.05). Conclusion There is a close relationship between serum Hcy and carotid atherosclerosis in patients with chronic cerebral hypoperfusion, which may indicate the risk of stroke.